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The Indirect Coombs Test is a blood test used to detect antibodies in the blood that could potentially cause the destruction of red blood cells. It's particularly useful in evaluating conditions like hemolytic disease in newborns, compatibility in blood transfusions, or detecting antibodies in certain autoimmune disorders.

The Indirect Coombs Test detects antibodies in the blood that haven't yet attached to the surface of red blood cells. In contrast, the Direct Coombs Test identifies antibodies that are already attached to red blood cells. The indirect version is primarily used in screening for antibody presence, while the direct test is more focused on diagnosing specific autoimmune or hemolytic conditions.

An Indirect Coombs Test is typically ordered during pregnancy to screen for Rh incompatibility between a mother and her baby. It's also used before a blood transfusion to ensure compatibility between donor and recipient blood types or in cases where there's suspicion of autoimmune hemolytic anemia. Your healthcare provider will recommend this test based on specific medical conditions or concerns.